Directed by Steven Soderbergh, "Behind the Candelabra" is a biopic about the last 10 years in the life of pianist Liberace and the secret affair he had with his friend Scott Thorson, played by actor Matt Damon.
Amidst the news of marriage trouble, Michael Douglas, 68, walked the red carpet alone, but thanked his wife, actress Catherine Zeta-Jones and his three children - Cameron, Dylan, Carys, after receiving the award.
This is Douglas' first Primetime Emmy Award and fifth nomination.
"Behind the Candelabra" also won the best miniseries/movie award.
The lead actress trophy at the 65th Primetime Emmy Awards was taken by actress Laura Linney for her character Cathy in the miniseries "The Big C: Hereafter". This is her fourth Emmy Award, she previously won the award for "Frasier", "Wild Iris" and "John Adams".
Other nominations in the category were Jessica Lange for "American Horror Story: Asylum", Elisabeth Moss for "Top of the Lake", Helen Mirren for "Phil Spector", and Sigourney Weaver for "Political Animals".
Primetime Emmy Awards announced
The 65th Primetime Emmy Awards were announced at the Nokia Theatre here Sunday.
The show, hosted by actor Neil Patrick Harris, saw performances by singers Elton John and Carrie Underwood.
The star-studded event marked the presence of actors like Michael Douglas, Matt Damon, Al Pacino, Alec Baldwin, and Jimmy Kimmel.
While Harris entertained the audience with his vibrant hosting, it was his impromptu dance to a musical "It's the number in the middle of the show" that was well-received.
Shows like "Modern Family", "Breaking Bad", "Behind the Candelabra" and "The Colbert Report" went back home with more than one trophy.
The show also gave tribute to actors who passed away, including "Glee" star Cory Monteith and "The Sopranos" actor James Gandolfini.
Another special feature of the award ceremony was the addition of the outstanding choreographer award, which was bagged by Derek Hough for dance reality show "Dancing With the Stars".
(Photo: Michael Douglas at Cannes premiere of 'Behind the Candelabra' earlier this year - IANS/Xinhua/Zhou Lei)