Jaikishen was born in the Gujerati-speaking Shroff family on February 1, 1957. His dad's name is Kakubhai, his brother's is Hemant, and they live in Bandra, Bombay in a bungalow named 'Le Pepeyon".A vegetarian, Jaikishen made his Bollywood debut in a bit-role as a villain in the 1973 hit 'Heera Panna' which starred Dev Anand. He then went on to act in another Dev Anand starer, 'Swami Dada".It was Subhash Ghai, who signed him up for the 1983 hit 'Hero' that catapulted this handsome young man to stardom, followed by yet another hit 'Andar Bahar' with Anil Kapoor as his co-star. Thus Jaikishen became the new Bollywood legend: Jackie Shroff.Since then there has been no looking back, as he went on to star in close to 150 movies with a career that spanned from 1973 onwards. Since 2000 or thereabouts he has appeared in a variety of character-roles, villain, comedian, and even as a ghost in 'Bhoot Unkle'.He married his longtime girlfriend, Ayesha Dutt, who is also a producer and both husband and wife run Jackie Shroff Entertainment Limited. They have two children, a son, Jai (nickname Tiger), and a daughter, Krishna.

Has two children, a son and a daughter.

On June 16, 2005, he admitted to being a fan of the former actress Asha Parekh.